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4F-PHP, also known as 1-(4-Fluorophenyl)homopiperazine dihydrochloride and 4-FPHP•2HCl, is one of a family of piperazine derivatives and analogies which are both euphorics and psychedelics, to varying degrees.
4-FPHP and other piperazines have been sold as a recreational drug in New Zealand and other countries under the name ‘Party Pills’ as early as 2003. It has also been detected in brands including ‘Extreme Beans’ and ‘The big Grin’.
These piperazine derivatives function mostly as agonists for the 5-HT1A chemoreceptors, as well as to a lesser degree the 5-HT2C receptors. There is usually some difference of opinion whether 4-FPHP actually stimulates the release of norepinephrine and serotonin, or merely acts to slow their reuptake, but it is known to interact strongly with those systems.
Many piperazine derivatives are illegal in New Zealand, but 4F-PHP may not yet be listed as one of them. As always, researchers should check with local authorities.
4F-PHP, like the other piperazine derivatives, neither approved nor suitable for human consumption. It is intended limited to trained analysis chemists and laboratory employees.